TG101348

Code Description Price Qty
SM103-1 TG101348, 1 mg £30.00
SM103-5 TG101348, 5 mg £85.00
SM103-10 TG101348, 10 mg £155.00
SM103-50 TG101348, 50 mg £470.00
TG101348

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor.TG101348 also inhibits FLT3 and RET.

Effect

TG101348 exhibits promising pharmacokinetic profiles. TG101348 inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.

Alternative Names

SAR302503

N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide

References

1. Wernig, G., et al. 2008. Cancer Cell. 13(4): 311-320. PMID: 18394554

2. Ye, Z., et al. 2014. Stem Cells. 32(1): 269-278. PMID: 24105986

3. Mullally A., et al. 2010. Cancer Cell. 17(6): 584-596. PMID: 20541703

Product Details
Formula C27H36N6O3S
Molecular Weight 524.68
CAS Number 936091-26-8
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.