TG101348
TG101348
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
TG101348 is a selective small-molecule Janus kinase 2 (JAK2) inhibitor.TG101348 also inhibits FLT3 and RET.
Effect
TG101348 exhibits promising pharmacokinetic profiles. TG101348 inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.
Alternative Names
SAR302503
N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide
References
1. Wernig, G., et al. 2008. Cancer Cell. 13(4): 311-320. PMID: 18394554
2. Ye, Z., et al. 2014. Stem Cells. 32(1): 269-278. PMID: 24105986
3. Mullally A., et al. 2010. Cancer Cell. 17(6): 584-596. PMID: 20541703
| Product Details | |
|---|---|
| Formula | C27H36N6O3S |
| Molecular Weight | 524.68 |
| CAS Number | 936091-26-8 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
