TWS119

Code Description Price Qty
SM105-2 TWS119, 2 mg $57.00
SM105-10 TWS119, 10 mg $165.00
SM105-25 TWS119, 25 mg $309.00
SM105-50 TWS119, 50 mg $556.00
TWS119

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

TWS119 is a cell-permeable pyrrolopyrimidine compound that acts as a glycogen synthase kinase-3 beta (GSK-3 beta) inhibitor. TWS119 is thought to bind GSK-3 beta with high-affinity and increases the level of beta-catenin, a downstream substrate of GSK-3 beta in the Wnt signaling pathway.

Effect

TWS119 induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESC). Because neuronal differentiation can be achieved without embryoid bodies (EB) formation and RA treatment, TWS119 may act by a novel mechanism on early processes involved in determining cell fate. TWS119 treatment towards hepatic stellate cells leads to reduced β-catenin phosphorylation, induces nuclear translocation of β-catenin, elevates glutamine synthetase production, impedes synthesis of smooth muscle actin and Wnt-5a, but promotes the expression of glial fibrillary acidic protein, Wnt-10b, and paired-like homeodomain transcription factor 2c.

Alternative Names

GSK-3β Inhibitor XII

3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol

References

1. Kordes, C., et al. 2008. Biochem Biophys Res Commun. 367(1): 116-123. PMID: 18158920

2. Ding, S., et al. 2003. Proc Natl Acad Sci U S A. 100(13): 7632-7637. PMID: 12794184

3. Forget, MA., et al. 2012. PLoS One. 7(7): e41074. PMID: 22859966

4. Ono, M., et al. 2011. Platelets. 22(3): 196-203. PMID: 21231855

Product Details
Formula C18H14N4O2
Molecular Weight 318.33
CAS Number 601514-19-6
Purity >98%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.