Vandetanib

Code Description Price Qty
SM107-2 Vandetanib, 2 mg $60.00
SM107-25 Vandetanib, 25 mg $175.00
SM107-100 Vandetanib, 100 mg $251.00
SM107-500 Vandetanib, 500 mg $929.00
Vandetanib

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

Vandetanib is an antagonist of VEGFR and EGFR families. Specifically inhibits kinase activity of Flk-1. It is also an inhibitor of Flt-4. Vandetanib is not sensitive to PDGFR beta, Flt1, Tie-2 and FGFR1, while almost has no activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R.

Effect

Vandetanib has been shown to influence in the osteoblast differentiation process in-vitro.

Alternative Names

Caprelsa, Zactima, ZD6474

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

References

1. Wedge, SR., et al. 2002. Cancer Res. 62(16): 4645-4655. PMID: 12183421

2. Arbab, AS. 2012. Histol Histopathol. 27(5): 549-557. PMID: 22419019

3. Alemán, JO. et al. 2014. Endocr Relat Cancer. 21(3): R247-259. PMID: 24478055

Product Details
Formula C22H24BrFN4O2
Molecular Weight 475.35
CAS Number 443913-73-3
Purity >99%
Solubility DMSO, ethanol
Stability and Storage Stable at -20°C. Keep away from direct sunlight.