XAV939
XAV939
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
XAV939 is a beta-catenin-mediated transcription inhibitor of selective Wnt pathway. Alternatively, it acts as axin stabilizing agent for the inhibition of TNKS1 and TNKS2.
Effect
XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line.
Alternative Names
XAV 939, XAV-939
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
References
1. Smith, S., et al. 1998. Science. 282(5393): 1484-1487. PMID: 9822378
2. Huang, SM., et al. 2009. Nature. 461(7264): 614-620. PMID: 19759537
| Product Details | |
|---|---|
| Formula | C14H11F3N2OS |
| Molecular Weight | 312.31 |
| CAS Number | 284028-89-3 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
