Cell proliferation, self-renewal and differentiation are regulated by protein signalling cascades. Growth factors, transcription factors, and other components of signal transduction pathways all combine to coordinate this behaviour. These signalling pathways can be modulated by naturally occurring and synthetic small molecules which bind to individual components of the pathway. When binding causes modification of the target molecule’s activity, the pathway can be disrupted. By targeting a particular pathway, it is possible to enhance cell proliferation and direct fate decisions.
Cell Guidance Systems offers a selected range of bioactive small molecules for stem cell research.
When using small pack sizes (below 10 mg), researchers typically resuspend the entire contents of the product in their resuspension buffer without a further weighing of the contents. However, for really small amounts how confident can you be in the accuracy of the weight stated on the label? For our smallest pack sizes, we provide data on the Exact Amount™ of product that is contained within the vial. You can then be assured that the concentration you obtain following resuspension is the concentration you want. All Exact Amount™ vials are measured using our Trade Certified state-of-the-art semi-micro balances set up in fume hoods with isolated fan enclosures for absolute balance stability and optimal accuracy. The amount of product included in each Exact Amount™ vial is specified on the label to two decimal places. For example, 2 mg vials will contain an amount that typically varies between 2.00 mg and 2.50 mg. This Exact Amount™ is stated on the vial label. Together with high quality and keen pricing, this is just one of the ways CellGS is helping scientists achieve their research goals.
Image Credit: Antidepressant drug blocking dopamine transporter protein. Credit: RCSB Protein Data Bank. Attribution 4.0 International (CC BY 4.0)