Critical gaps between experimental models and clinical reality are the reason why clinical trials of promising drugs often fail. Closing those gaps can save huge amounts of money lost to failed trials. The right scaffold is critical to model accuracy
When researchers at the University of Helsinki set out to understand how the mechanical properties of breast tumors affect immune cell behavior, they needed a culture system that could faithfully recreate different tissue environments. Their choice of PeptiGel as a 3D culture matrix proved instrumental in uncovering a surprising mechanism of immune suppression in breast cancer.
Molecular structure such as small molecules and proteins are typically measure in Daltons. Whereas larger structures are measure in grams. Here we explain why, and how these units they relate to each other.
Affinity-based biosensors use antibodies or aptamers to detect cytokines but suffer from slow dissociation kinetics (half-lives up to ~20 hours). Addressing this kinetic bottleneck enables real-time monitoring of concentration.
Providing building blocks for controlled protein release, the inspired use of PODS is enabling research breakthroughs across biomedical science.
Last week, a Nobel prize was awarded for the discovery of T-Reg cells. When and how many immune cells have been identified and are there likely more lurking in the shadows?
Poor survival of implanted retinal cells has held back therapeutic development. Sustained neurotrophic growth factor release is pushing the field forwards
Sustained release PODS-TGF-B2 enabled powerful modelling of trabecular meshwork,
Rising sea levels, extreme weather, and ecosystem disruption, are well known consequences of climate change, but emerging research also reveals a more intimate threat: climate change may be directly damaging our chromosomes and altering our genetic makeup. This hidden consequence could have profound implications for human health and evolution.
Biological research standards are the invisible agreements that make life science actually scientific. Creating these standards is more complicated (and political) than most people realize.
