Cell Guidance Systems Blog

In our immune system's fight against cancer, autologous immune cell therapy using CAR-T cells has transformed treatment options for patients with leukaemia and lymphoma but is not effective against solid tumors. Could monocytes and their derivatives, notably macrophages, succeed where CAR-T cells have failed? Here we look at the way cancers try to exert dominance over macrophages and the companies rising to the challenge of autologous macrophage therapy.

When we think about the building blocks of life, our minds often jump to cells, DNA, and proteins. However, lurking in the spaces between cells is an equally crucial component that often goes unnoticed: the extracellular matrix (ECM). This unsung hero plays a pivotal role in maintaining the structure and function of tissues, influencing everything from wound healing to cancer progression.

Calorie restriction (CR) has long been recognized to increase both health span (the duration of a healthy life) and lifespan, but is difficult to adhere to. Recently published papers indicate that a dietary supplement (also produced by some gut microbes) can achieve the same effect.

Viral vectors, such as AAV, are used for the delivery of RNA and DNA therapeutics. Machine learning, a type of AI, is enabling the rapid iterative development and improvement of these therapeutic vectors.

Pressure regulation, valves, and balanced distribution: A domestic heating system and the human circulatory system share a remarkably wide range of similarities.

The activity of a cell is organised by a range of structures, from large organelles to small protein complexes. Amongst these, each cell contains around 100,000 ellular vaults, or simply vaults. These are enigmatic mid-size symmetrical cellular ribonucleoprotein structures that play a role in the storage and transport of molecules within cells.

In biomanufacturing, growth factors and cytokines are crucial for the cultivation and maintenance of cell cultures, particularly in the production of therapeutic proteins, vaccines, and other biologics. Just a few growth factors are widely used.

Animal cells grown in a cell culture conditions play a pivotal role in both research and biomanufacturing, serving as essential tools for scientific discovery and the production of complex biological products. Their use spans a wide range of applications, from basic biological research to the production of vaccines, therapeutic proteins and food.

Research relies on standards. For extracellular vescicles, a common language has been developed that allows a shared understanding and interpretation of data across labs.

Karyotyping remains an important assay when working with any animal cell. Here we discuss the benefits and limitations.